Safety
Is DHM safe? Side effects, the liver and the right dose
The short answer: the research so far is reassuring. Let’s look together at what the studies and the NIH’s liver-safety database say about DHM, and how the 650 mg in each Good Spirits serving fits in.
Written by Darren Lee, Pharmacist · Founder, Attune RX
Published November 2, 2026 · Updated November 2, 2026 · 5 min read
Key takeaways
- Good news for your liver: the NIH’s LiverTox database reports that DHM has not been linked to liver enzyme elevations or liver injury, and rates it an unlikely cause of liver injury.
- Short human studies, including twice-daily use for three months, reported no adverse events.
- For long-term daily use, two capsules a day is the amount to stay with: 650 mg DHM, within the 300 to 1,000 mg a day that LiverTox describes as typical. A daily DHM supplement has been studied for 12 months.
- Please check with your pharmacist first if you take prescription medication, have a liver or kidney condition, or are pregnant or nursing.
Is DHM safe?
For healthy adults using it as directed, the evidence so far is reassuring. I know that’s the first thing you want to hear about anything you take, so here’s where it comes from. The NIH’s LiverTox database, which tracks liver injury from drugs and supplements, describes DHM as widely reported to be well tolerated and without side effects, and notes that the few short human studies have reported no adverse events or signs of toxicity.[1] Research now includes a full year of daily use, so Good Spirits can be part of your everyday routine at two capsules a day.
How much DHM is in Good Spirits?
Each two-capsule serving has 650 mg of DHM. LiverTox describes typical DHM doses as 300 to 1,000 mg a day,[1] so each serving sits nicely in the middle of that range. For everyday use, one serving a day is the amount to stay with. On nights out, take one serving before your first drink and one the next morning.*
| Ingredient | Per serving | Before + next morning |
|---|---|---|
| DHM (dihydromyricetin) | 650 mg | 1,300 mg |
| Clove extract (Syzygium aromaticum) | 200 mg | 400 mg |
| Taurine | 100 mg | 200 mg |
| Choline (L-bitartrate) | 100 mg | 200 mg |
| B-complex (B1, B2, B3, B5, B6, B12) | High potency | Two servings |
What do human studies show about side effects?
Short human studies so far have reported no adverse events, which is reassuring to see. Here’s what each one found:
- Three months of daily use. LiverTox summarizes a randomized trial in which 60 adults took 150 mg of DHM or a placebo twice a day for three months, with no adverse events in either group.[1]
- One month at a higher dose. In another trial it summarizes, 80 adults took 760 mg of a DHM-rich vine tea extract or a placebo once a day for a month, and neither group had any adverse reactions.[1]
- Hangover studies. A 2022 review of placebo-controlled hangover trials, including trials of Hovenia (raisin tree) fruit extract, a natural source of DHM, found no drop-outs because of side effects and described the remedies studied as having favourable tolerability profiles.[2]
Can you take DHM every day?
Yes, you can, and there’s now a full year of research behind that answer. In a 12-month randomized trial, adults took a daily DHM-based supplement (with vitamins C and E and choline) or a placebo for a year, and the researchers reported excellent tolerability and no drug-related adverse events.[3] Shorter trials summarized by LiverTox, of one to three months of daily use, also reported no adverse events.[1] For long-term use, two capsules of Good Spirits a day (650 mg DHM) is the amount to stay with. A 40-capsule bottle lasts 20 days, so it’s easy to plan ahead.
Is DHM safe for your liver?
Based on what we know so far, the answer is encouraging: no liver injury has been linked to DHM. This is the question I hear most, so let me share the details. LiverTox reports no case reports of liver injury attributed to DHM, notes that it doesn’t appear in large case series or reviews of supplement-related liver injury, and rates it “E”: an unlikely cause of clinically apparent liver injury.[1]
Does DHM help your liver?
In animal research, it looks promising. In mice given alcohol, DHM reduced fat buildup and inflammation in the liver and boosted the enzymes that break alcohol down.[4] That research is why DHM leads the Good Spirits formula, to support alcohol metabolism.* I do want to be clear that it hasn’t been shown to treat liver disease in people, so if you have a liver condition, please talk to your doctor before taking it.
And one tip, whatever you take: it’s best to skip acetaminophen (Tylenol) around drinking, because combined with alcohol it can be toxic to the liver.[5]
Does DHM interact with medications?
It might, so a quick check is worth it. In a lab study using human liver enzymes, DHM slowed three enzymes (CYP3A4, CYP2E1 and CYP2D6) that the body uses to process many medicines. The authors said clinical studies are needed to know whether this matters in people.[6] If you take prescription medication, including blood thinners, please ask your pharmacist before using Good Spirits. It only takes a minute, and we’re always glad to help.
Are the other ingredients safe?
They’re familiar ingredients, and every dose is on the label with no proprietary blend, so you and your pharmacist can see exactly what you’re taking:
| Ingredient | Per serving | What to know |
|---|---|---|
| DHM (dihydromyricetin) | 650 mg | Not linked to liver injury in LiverTox; typical doses 300 to 1,000 mg a day[1] |
| Clove extract | 200 mg | From a familiar kitchen spice; if you take blood thinners, check with your pharmacist |
| Taurine | 100 mg | Found naturally in foods such as meat and fish |
| Choline | 100 mg | 200 mg across the routine, under 6% of the 3,500 mg daily upper limit for adults[7] |
| B-complex | High potency | If you also take another B-vitamin supplement, give the label a quick look |
Who should check with a doctor or pharmacist first?
A quick conversation with your doctor or pharmacist is a good idea if any of these apply to you:
- You take prescription medication, including blood thinners.
- You have a liver or kidney condition.
- You’re pregnant or nursing: Good Spirits hasn’t been studied in pregnancy.
- Good Spirits is made for adults 21 and over.
One friendly reminder: Good Spirits doesn’t sober you up or make it safe to drive, and it’s never a reason to drink more.
Common questions
Is DHM safe to take?
For healthy adults using it as directed, the research so far is reassuring: the NIH’s LiverTox database reports no liver injury linked to DHM, and short human studies reported no adverse events.
Does DHM have side effects?
The short human studies summarized by LiverTox reported no adverse events. If you ever notice anything unusual, please stop taking it and check in with your doctor or pharmacist.
Is DHM bad for your liver?
No liver injury has been linked to DHM, and LiverTox rates it an unlikely cause of clinically apparent liver injury. If you have a liver condition, it’s still best to check with your doctor first.
Can I take DHM every day?
Yes. For long-term daily use, two capsules of Good Spirits a day (650 mg DHM) is the amount to stay with. A daily DHM supplement has been studied for 12 months with excellent tolerability. On nights out, switch to two capsules before your first drink and two the next morning.
References
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Dihydromyricetin. National Institute of Diabetes and Digestive and Kidney Diseases. Updated August 16, 2023. Source
- Roberts E, Smith R, Hotopf M, Drummond C. The efficacy and tolerability of pharmacologically active interventions for alcohol-induced hangover symptomatology: a systematic review of the evidence from randomised placebo-controlled trials. Addiction. 2022;117(8):2157-2167. Source
- Michailidou E, et al. Dietary supplement based on dihydromyricetin in metabolic dysfunction-associated steatotic liver disease: a double-blind, placebo-controlled, randomized clinical trial. Ann Gastroenterol. 2026;39(1):54-62. Source
- Silva J, et al. Dihydromyricetin protects the liver via changes in lipid metabolism and enhanced ethanol metabolism. Alcohol Clin Exp Res. 2020;44(5):1046-1060. Source
- National Institute on Alcohol Abuse and Alcoholism (NIAAA). Hangovers. Updated December 2025. Source
- Liu L, Sun S, Rui H, Li X. In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes. Pharm Biol. 2017;55(1):1868-1874. Source
- NIH Office of Dietary Supplements. Choline: fact sheet for health professionals. Source
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This article is for general education and is not medical advice. Please drink responsibly. Must be 21+.